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Dr. Lee was born in Shanghai, China in 1936 and received a bachelors degree from National Taiwan University. He came to Northwestern in 1971 to do research in the Department of Obstetrics and Gynecology in the field of endocrinology, and subsequently joined the Department of Urology as Director of the Urology Research Laboratory. In the succeeding years, his productivity has advanced him to the level of full Professor and to a joint appointment with the Department of Cell and Molecular Biology. Under his direction, the laboratories have grown steadily and produced a large volume of basic research. To honor Dr. John Grayhack’s service as chair of the Department of Urology, funds were raised for the John T. Grayhack Professorship in Urological Research, and Dr. Lee was named as the first recipient in 1992. Undergraduate: Animal Science, National Taiwan University, Taiwan
Graduate (MS): Physiology/Nutrition, West Virginia University, Morgantown, WV
Graduate (PhD): Physiology/Nutrition, West Virginia University, Morgantown, WV
Post-graduate: Biochemistry, Albany Medical College, Albany, NY The following publications are selected from a total of 176 journal articles. For more information on Dr. Lee's scholarly productivity, please contact his office. - Ilio KY, Grayhack JT, Lee C. Experimental cryptorchidism inhibited growth of the rat ventral prostate. J Androl. 21(3):438-43. 2000.
- Ilio KY, Nemeth JA, Sensibar JA, Lang S, Lee C. Prostatic ductal system in rats: changes in regional distribution of extracellular matrix proteins during castration-induced regression. Prostate. 43(1):3-10. 2000.
- Kundu SD, Kim IY, Yang T, Doglio L, Lang S, Zhang X, Buttyan R, Kim SJ, Chang J, Cai X, Wang Z, Lee C. Absence of proximal duct apoptosis in the ventral prostate of transgenic mice carrying C3(1)-TGF-beta type II dominant receptor. Prostate. 43(2):118-24. 2000.
- Janulis L, Nemeth JA, Yang T, Lang S, Lee C. Prostatic luminal cell differentiation and prostatic steroid-binding protein (PBP) gene expression are differentially affected by neonatal castration. Prostate. 43(3):195-204. 2000.
- Kong X, Zeng L, Yang Y, Xia T, Gu F, Guo Y, Lee C. Immunohistochemical characterization of stromal nodules in benign prostatic hyperplasia. The Prostate Journal. 2(4):199-204. 2000.
- Matthews E, Yang T, Janulis L, Goodwin S, Kundu SD, Karpus WJ, Lee C. Down regulation of TGF-beta1 production restores immunogenicity in prostate cancer cells. Br J Cancer. 83(4):519-25. 2000.
- Kassen A, Sensibar JA, Sintich SM, Kozlowski JM, Lee C. Autocrine effect of DHT on basic FGF signaling and cell proliferation in LNCaP cells: role of heparin/heparan degrading enzymes. Prostate. 44(2):124-32. 2000.
- Zhang X, Lee C, Ng PY, Rubin M, Shabsigh A, Buttyan R. Prostatic neoplasia in transgenic mice with prostate-derived overexpression of the c-myc oncoprotein. Prostate. 43(4):278-85. 2000.
- Lee C. The future of academic urologists. J Urol. 163(6):1888-9. 2000.
- Lee C, Janulis L, Ilio K, Shah A, Park I, Kim S, Cryns V, Pins M, Bergan R. In vitro models of prostate apoptosis: clusterin as an antiapoptotic mediator. Prostate Suppl. 9:21-4. 2000.
- Shah AH, Lee C. TGF-beta-based immunotherapy for cancer: breaching the tumor firewall. Prostate. 45(2):167-72. 2000.
- Ilio KY, Park II, Pins MR, Kozlowski JM, Lee C. Apoptotic activity of doxazosin on prostate stroma in vitro is mediated through an autocrine expression of TGF-beta1. Prostate. 48(3):131-5. 2001.
- Kramer G, Steiner GE, Handisurya A, Stix U, Haitel A, Knere B, Gessl A, Lee C, Marberger M. Increased expression of lymphocyte-derived cytokines in benign hyperplastic prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines stromal cell proliferation. Prostate. 52(1):43-58. 2002.
- Wu AJ, Park II, Zhaung L, Lee C. Response to a lethal dose of heat shock by a transient up-regulation of clusterin expression followed by down-regulation and apoptosis in prostate and bladder cancer cells. Prostate. 53(4):277-85. 2002.
- Zhou W, Janulis L, Park II, Lee C. A novel anti-proliferative property of clusterin in prostate cancer cells. Life Sci. 72(1):11-21. 2002.
- Shah AH, Tabayoyong WB, Kim SJ, Van Parijs L, Kimm S, Lee C. Reconstitution of lethally irradiated adult mice with dominant negative TGF-beta type II receptor-transduced bone marrow leads to myeloid expansion and inflammatory disease. J Immunol. 169(7):3485-91. 2002.
- Shah AH, Tabayoyong WB, Kundu SD, Kim SJ, Van Parijs L, Liu VC, Kwon E, Greenberg NM, Lee C. Suppression of tumor metastasis by blockade of transforming growth factor beta signaling in bone marrow cells through a retroviral-mediated gene therapy in mice. Cancer Res. 62(24):7135-8. 2002.
- Liu YQ, Jovanovic B, Pins M, Lee C, Bergan RC. Over expression of endoglin in human prostate cancer suppresses cell detachment, migration and invasion. Oncogene. 21(54):8272-81. 2002.
- Huang X, Lee C. From TGF-beta to cancer therapy. Curr Drug Targets. 4(3):243-50. 2003.
- Doll JA, Stellmach VM, Bouck NP, Bergh AR, Lee C, Abramson LP, Cornwell ML, Pins MR, Borensztajn J, Crawford SE. Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas. Nat Med. 9(6):774-80. 2003.
- Steiner GE, Newman ME, Paikl D, Stix U, Memaran-Dagdar NM, Lee C, Marberger MJ. Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Prostate. 56(3):171-82. 2003.
- Lee C. Research enterprise in urology: a message to the urology leadership. J Urol. 170(1):189-91. 2003.
- Zhou W, Park I, Pins M, Kozlowski JM, Jovanovic B, Zhang J, Lee C, Ilio K. Dual regulation of proliferation and growth arrest in prostatic stromal cells by transforming growth factor-beta1. Endocrinology. 144(1):4280-4. 2003.
- Huang X, Lee C. Regulation of stromal proliferation, growth arrest, differentiation and apoptosis in benign prostatic hyperplasia by TGF-beta. Front Biosci. 8:s740-9. 2003.
- Grayhack JT, Smith ND, Ilio K, Wambi C, Kasjanski R, Crawford SE, Doll JA, Wang Z, Lee C, Kozlowski J. Pigment epithelium-derived factor, a human testis epididymis secretory product, promotes human prostate stromal cell growth in culture. J Urol. 171(1):434-8. 2004.
Northwestern University, Feinberg School of Medicine
Department of Urology
303 East Chicago Avenue, Tarry 16-703
Chicago, IL 60611-3008
(312) 908-2004
Fax (312) 908-7275
c-lee7@northwestern.edu Sharon Stafford
Administrative Assistant
(312) 908-8600
s-stafford@northwestern.edu
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